New paradigms in primary immunodeficiencies

Abstract

Primary Immunodeficiencies are characterized by a dysfunctional immune system, resulting in susceptibility to infections, autoimmune, allergic and malignant diseases. These entities are more common than generally believed. Nevertheless, there is not enough awareness about this topic among physicians. There is a gap between research and clinical practice. Many options are available for the patients, but as misdiagnosis is frequent, they do not have access to them. This increased morbidity and decreased quality of life and life span. Therefore, health care professionals should be informed about all the possibilities and developments in the matter.